Preben von Magnus

Preben von Magnus (1912–1973) was a Danish virologist and physician known for his significant contributions to the field of virology, particularly in the study of influenza viruses. He is best known for his discovery of the "von Magnus phenomenon," which describes the production of defective interfering particles during viral replication.

Early Life and Education

Preben von Magnus was born in Copenhagen, Denmark, in 1912. He pursued his medical studies at the University of Copenhagen, where he developed an interest in microbiology and virology. After completing his medical degree, von Magnus continued his research in virology, focusing on the mechanisms of viral infections.

Career and Research

Von Magnus began his career at the Statens Serum Institut in Copenhagen, where he worked alongside other prominent virologists. His research primarily focused on the influenza virus, and he made several groundbreaking discoveries in the field.

The von Magnus Phenomenon

One of von Magnus's most notable contributions to virology is the discovery of the "von Magnus phenomenon." This phenomenon describes the production of defective interfering particles (DIPs) during the replication of certain viruses, including the influenza virus. These DIPs are incomplete viral particles that can interfere with the replication of standard virus particles, thereby modulating the course of the infection.

Contributions to Influenza Research

Von Magnus's work on the influenza virus extended beyond the von Magnus phenomenon. He also contributed to the understanding of viral pathogenesis, immune response to viral infections, and the development of vaccines. His research has had a lasting impact on the field of virology and has paved the way for further studies on viral interference and vaccine development.

Legacy

Preben von Magnus's contributions to virology have been widely recognized and continue to influence the field. His discovery of the von Magnus phenomenon has provided valuable insights into viral replication and the development of antiviral strategies. Von Magnus passed away in 1973, but his legacy lives on through his pioneering research and the continued study of defective interfering particles.

See Also

• Virology
• Influenza
• Defective interfering particle
• Statens Serum Institut
• University of Copenhagen