Progressive transformation of germinal centres
| Progressive transformation of germinal centres | |
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| Progressive transformation of germinal centres -1- very low mag.jpg | |
| Micrograph of a lymph node biopsy showing progressive transformation of germinal centres. H&E stain. | |
| Synonyms | progressive transformation of germinal centers
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| Specialty | Infectious disease
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Progressive transformation of germinal centres (PTGCs) is a reactive lymph node process of undetermined cause.
Signs and symptoms[edit]
PTGC is usually characterized by localized lymphadenopathy and is otherwise typically asymptomatic.
Diagnosis[edit]
PTGC is diagnosed by surgical excision of the affected lymph node(s), and examination by a pathologist. The differential diagnosis includes non-neoplastic causes of lymphadenopathy (e.g. cat-scratch fever, Kikuchi disease) and malignancy, i.e. cancer.
Microscopic appearance[edit]
PTGCs is characterized by:[1]
- follicular hyperplasia (many follicles),
- focally large germinal centres, with poorly demarcated germinal centre (GC)/mantle zone interfaces (as GCs infiltrated by mantle zone lymphocytes), and
- an expanded mantle zone.
Treatment[edit]
PTGC is treated by excisional biopsy and follow-up. It may occasionally recur and in a small proportion of patients has been reported to subsequently develop Hodgkin lymphoma (usually nodular lymphocyte predominant Hodgkin lymphoma).[2][3]
See also[edit]
References[edit]
- ↑ "Progressive transformation of germinal centers. Report of 2 cases and review of the literature".Acta Haematol..2002;108(1)
- 33–8.doi:10.1159/000063057.PMID:12145465.
- ↑ "Progressive transformation of germinal centers with and without association to Hodgkin's disease".Am. J. Clin. Pathol..February 1990;93(2)
- 219–26.PMID:2405631.
- ↑ "Progressive transformation of germinal centers: a clinicopathological study of 42 Japanese patients".Int. J. Surg. Pathol..April 2003;11(2)
- 101–7.doi:10.1177/106689690301100205.PMID:12754626.
