Prohibitin
Prohibitin (also known as PHB) is a protein that in humans is encoded by the PHB gene. It is a highly conserved protein, found in a wide range of species from humans to yeast. Prohibitin has been implicated in a variety of cellular functions, including mitochondrial integrity, cell cycle regulation, and apoptosis.
Function[edit | edit source]
Prohibitin is a ubiquitously expressed protein that is located primarily in the mitochondria. It forms a ring-like structure in the inner mitochondrial membrane, where it functions to maintain mitochondrial integrity and function. Prohibitin is also found in the nucleus and plasma membrane, suggesting that it may have additional roles outside of the mitochondria.
In addition to its role in mitochondrial function, prohibitin has been implicated in the regulation of cell cycle progression and apoptosis. It has been shown to inhibit cell proliferation and to promote cell cycle arrest in the G0/G1 phase. Prohibitin has also been shown to have anti-apoptotic activity, protecting cells from apoptosis induced by various stimuli.
Clinical significance[edit | edit source]
Alterations in prohibitin expression have been associated with a variety of diseases, including cancer, obesity, and aging. Overexpression of prohibitin has been observed in several types of cancer, including breast cancer, ovarian cancer, and lung cancer, and has been associated with poor prognosis. In contrast, reduced expression of prohibitin has been associated with obesity and aging.
Research[edit | edit source]
Research into the function and regulation of prohibitin is ongoing. Current areas of interest include the role of prohibitin in mitochondrial function and cell cycle regulation, the mechanisms by which prohibitin expression is altered in disease, and the potential use of prohibitin as a therapeutic target in cancer and other diseases.
See also[edit | edit source]
References[edit | edit source]
This article is a cell biology stub. You can help WikiMD by expanding it!
Aging stubs | |
|---|---|
| Overview | |
| Key Topics | |
| Related Topics | |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
