Propoxyphene napsylate

Propoxyphene Napsylate is a narcotic analgesic drug that was formerly used for the relief of mild to moderate pain. It is a member of the opioid class of drugs, which also includes substances such as morphine, codeine, and oxycodone.

Pharmacology

Propoxyphene Napsylate acts on the central nervous system (CNS) to produce analgesia, or pain relief. It is thought to exert its analgesic effects by binding to and activating mu-opioid receptors in the brain, spinal cord, and other parts of the body. This binding mimics the action of endogenous opioids (naturally occurring substances in the body), leading to a decrease in the perception of pain.

History

Propoxyphene Napsylate was first synthesized in the 1950s and was widely used for several decades. However, concerns about its safety and efficacy led to its withdrawal from the market in many countries. In 2010, the U.S. Food and Drug Administration (FDA) requested that all products containing propoxyphene be removed from the U.S. market due to the risk of potentially serious or even fatal heart rhythm abnormalities.

Side Effects

Like other opioids, Propoxyphene Napsylate can cause a number of side effects, including drowsiness, dizziness, constipation, and nausea. More serious side effects can include respiratory depression (slowed or stopped breathing), dependence and withdrawal, and potentially fatal overdose.

See Also

• Opioid
• Analgesic
• U.S. Food and Drug Administration