Proxyphylline

Proxyphylline is a cardiotonic drug that belongs to the xanthine family. It is used in the treatment of asthma, chronic obstructive pulmonary disease (COPD), and other respiratory disorders. Proxyphylline works by relaxing the smooth muscle in the airways, which allows for easier breathing.

Mechanism of Action

Proxyphylline is a bronchodilator that works by inhibiting phosphodiesterase enzymes. This leads to an increase in cyclic AMP and cyclic GMP, which in turn relaxes the smooth muscle in the airways and allows for easier breathing. Proxyphylline also has anti-inflammatory effects, which can help to reduce the symptoms of respiratory disorders.

Uses

Proxyphylline is used in the treatment of various respiratory disorders, including:

• Asthma
• Chronic obstructive pulmonary disease (COPD)
• Chronic bronchitis
• Emphysema

Side Effects

Like all medications, proxyphylline can cause side effects. These may include:

• Nausea
• Vomiting
• Headache
• Insomnia
• Tachycardia (rapid heart rate)
• Hypotension (low blood pressure)

Contraindications

Proxyphylline is contraindicated in patients with certain conditions, including:

• Cardiac arrhythmia
• Peptic ulcer
• Epilepsy

Interactions

Proxyphylline can interact with other medications, including:

• Theophylline
• Erythromycin
• Cimetidine
• Phenobarbital

Patients should inform their healthcare provider of all medications they are currently taking before starting treatment with proxyphylline.

See Also

• Xanthine
• Bronchodilator
• Phosphodiesterase inhibitor

Proxyphylline Resources
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