Quingestanol acetate
Quingestanol acetate is a steroidal progestin that was developed for use in hormonal contraception. It is a derivative of progesterone, a naturally occurring female sex hormone. Quingestanol acetate is not currently marketed in any country.
Pharmacology[edit | edit source]
Quingestanol acetate is a progestogen, meaning it has progestational activity similar to that of the natural hormone progesterone. It works by binding to and activating the progesterone receptor, which in turn inhibits the release of gonadotropins from the pituitary gland. This prevents ovulation and thus prevents pregnancy.
History[edit | edit source]
Quingestanol acetate was first synthesized in the 1960s by the pharmaceutical company Roussel Uclaf. It was initially marketed in combination with ethinylestradiol under the brand name "Demovis" for use as a contraceptive pill. However, it was later withdrawn from the market due to concerns about its safety and efficacy.
Side effects[edit | edit source]
Like all progestins, quingestanol acetate can cause a range of side effects. These can include menstrual irregularities, breast tenderness, mood changes, and weight gain. In rare cases, it can also cause more serious side effects such as blood clots and liver damage.
See also[edit | edit source]
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