R(+)XK469
<languages /><translate> The R-isomer of a synthetic quinoxaline phenoxypropionic acid derivative with proapoptotic and antiproliferative activities.
Mechanism of action
R(+)XK469 selectively inhibits topoisomerase II-beta, blocks activation of MEK/MAPK signaling kinases, stimulates caspases, and upregulates p53-dependent proteins, including cyclins A and B1, thereby arresting cancer cells in the G2/M phase of the cell cycle.
Other isomers
Both R(+) and S(-) isomers of this agent are cytotoxic, although the R-isomer is more potent. </translate>
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Contributors: Prab R. Tumpati, MD
