RCOR1

RCOR1 (REST Corepressor 1) is a protein that in humans is encoded by the RCOR1 gene. This protein is also known as CoREST, and it plays a crucial role in neural development and neurogenesis.

Function

The RCOR1 protein is a component of the CoREST complex, which is involved in the repression of neuronal genes in non-neuronal tissues. This complex is also required in neurons to prevent the aberrant expression of non-neuronal genes, thus maintaining the identity and function of neurons. The RCOR1 protein is known to interact with HDAC1 and HDAC2, two important enzymes involved in gene regulation.

Clinical Significance

Alterations in the RCOR1 gene have been associated with various neurological disorders, including autism, schizophrenia, and bipolar disorder. Further research is needed to fully understand the role of RCOR1 in these conditions.

See Also

• CoREST
• HDAC1
• HDAC2
• Gene regulation
• Neurological disorders

References

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.