ROR1

ROR1 (Receptor tyrosine kinase-like orphan receptor 1) is a protein that in humans is encoded by the ROR1 gene. ROR1 has a crucial role in the early development of the embryo and is believed to be significant in the progression of certain cancers.

Structure

ROR1 is a type I transmembrane protein that belongs to the ROR subfamily of cell surface receptors. The protein has two extracellular domains: an immunoglobulin-like domain and a cysteine-rich Frizzled-like domain. The intracellular region of ROR1 contains a tyrosine kinase domain.

Function

ROR1 is an oncogene that plays a critical role in the survival and migration of cancer cells. It is overexpressed in various types of cancers, including chronic lymphocytic leukemia (CLL), breast cancer, and lung cancer. The protein is believed to promote tumor growth by enhancing cell survival, proliferation, and invasion.

Clinical significance

ROR1 is a potential target for cancer therapy due to its overexpression in cancer cells and its absence in most normal adult tissues. Several therapeutic strategies are being developed to target ROR1, including monoclonal antibodies, small molecule inhibitors, and CAR-T cell therapy.

See also

• Receptor tyrosine kinase
• Oncogene
• Cancer therapy