RS-127445

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RS-127445 is a chemical compound that acts as a selective antagonist for the 5-HT2B receptor. It is primarily used in scientific research to study the role of the 5-HT2B receptor in various physiological and pathological processes.

Chemical Properties

RS-127445 has a molecular formula of C_19H_22N_2O_2 and a molecular weight of 310.39 g/mol. The compound is characterized by its high affinity and selectivity for the 5-HT2B receptor, making it a valuable tool in pharmacological studies.

Pharmacology

RS-127445 is known for its ability to selectively block the 5-HT2B receptor without significantly affecting other serotonin receptors such as 5-HT2A and 5-HT2C. This selectivity is crucial for research focused on the specific functions and implications of the 5-HT2B receptor.

Mechanism of Action

As a 5-HT2B receptor antagonist, RS-127445 binds to the receptor and inhibits its activation by endogenous ligands such as serotonin. This inhibition can help elucidate the role of the 5-HT2B receptor in various biological processes, including cardiovascular function, gastrointestinal motility, and central nervous system activities.

Research Applications

RS-127445 is widely used in preclinical studies to investigate the involvement of the 5-HT2B receptor in different diseases and conditions. Some of the key areas of research include:

• Cardiovascular disease: Studies have explored the role of the 5-HT2B receptor in heart failure, pulmonary hypertension, and other cardiovascular conditions.
• Gastrointestinal disorders: Research has examined the impact of 5-HT2B receptor antagonism on irritable bowel syndrome and other gastrointestinal motility disorders.
• Neurological disorders: The compound has been used to study the potential involvement of the 5-HT2B receptor in migraine, depression, and other neurological conditions.

Safety and Toxicity

The safety profile of RS-127445 has been evaluated in various preclinical studies. While it is generally considered safe for use in research, the compound's long-term effects and potential toxicity in humans have not been fully established.

Conclusion

RS-127445 is a potent and selective 5-HT2B receptor antagonist that serves as a valuable tool in scientific research. Its ability to selectively block the 5-HT2B receptor has provided insights into the receptor's role in various physiological and pathological processes, making it an important compound in the field of pharmacology.

See Also

• 5-HT2B receptor
• Serotonin
• Receptor antagonist
• Pharmacology