RS-127445

RS-127445 is a drug that acts as a selective antagonist for the serotonin receptor subtype 5-HT2B. It has been used in scientific research to investigate the function of this receptor, and has been found to have potential therapeutic applications in the treatment of pulmonary arterial hypertension and schizophrenia.

Pharmacology

RS-127445 is a highly potent and selective 5-HT2B receptor antagonist. It has over 1000-fold selectivity over other 5-HT2 receptor subtypes and other receptors such as the dopamine receptor and adrenergic receptor. This high selectivity makes it a useful tool in the study of 5-HT2B receptor function.

Therapeutic potential

Research has suggested that RS-127445 may have potential therapeutic applications. In animal models, it has been shown to reduce pulmonary arterial pressure, suggesting it may be useful in the treatment of pulmonary arterial hypertension. Additionally, it has been suggested that it may have antipsychotic effects, potentially making it useful in the treatment of schizophrenia.

See also

• 5-HT2B receptor
• Serotonin
• Pulmonary arterial hypertension
• Schizophrenia

References

RS-127445 Resources
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