Regramostim

From WikiMD's Wellness Encyclopedia



Regramostim is a recombinant form of granulocyte-macrophage colony-stimulating factor (GM-CSF), a cytokine that functions as a white blood cell growth factor. It is used primarily in the treatment of patients with neutropenia, a condition characterized by an abnormally low count of neutrophils, which are a type of white blood cell crucial for fighting off infections.

Mechanism of Action[edit | edit source]

Regramostim works by stimulating the bone marrow to produce more granulocytes and macrophages, which are essential components of the immune system. By binding to specific receptors on the surface of hematopoietic progenitor cells, regramostim activates intracellular signaling pathways that lead to the proliferation and differentiation of these cells into mature immune cells.

Clinical Uses[edit | edit source]

Regramostim is primarily indicated for patients undergoing chemotherapy who are at risk of developing neutropenia. It is also used in patients undergoing bone marrow transplantation to accelerate the recovery of the immune system. Additionally, regramostim may be used in the treatment of certain types of leukemia and other conditions where boosting the immune system is beneficial.

Administration and Dosage[edit | edit source]

Regramostim is typically administered via subcutaneous injection or intravenous infusion. The dosage and frequency of administration depend on the specific condition being treated, the patient's response to therapy, and other individual factors such as age and overall health.

Side Effects[edit | edit source]

Common side effects of regramostim include bone pain, fever, and fatigue. More serious side effects can include allergic reactions, capillary leak syndrome, and pulmonary edema. Patients receiving regramostim should be monitored for these adverse effects, and treatment should be adjusted accordingly.

Research and Development[edit | edit source]

Ongoing research is exploring the use of regramostim in various other conditions, including autoimmune diseases and infectious diseases. Studies are also investigating the potential of regramostim to enhance the efficacy of cancer immunotherapy by boosting the patient's immune response against tumor cells.

Also see[edit | edit source]

Template:Recombinant proteins

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Contributors: Prab R. Tumpati, MD