Retroprogesterone

Retroprogesterone is a type of progestogen that is structurally related to Progesterone. It is a class of medications and naturally occurring steroid hormones that interact with the progesterone receptor. Retroprogesterones are characterized by their modification at the C9(11) position of the steroid nucleus.

Chemistry

Retroprogesterones, also known as 9β,10α-progesterones, are synthetic progestogens derived from Progesterone. They are named for their structural modification at the C9(11) position, which is reversed, or "retro", compared to progesterone. This modification results in increased progestational activity.

Pharmacology

Retroprogesterones bind to and activate the Progesterone receptor, which mediates their biological effects. They have strong progestational activity and minimal androgenic activity. Some retroprogesterones, such as Dydrogesterone, also have antiestrogenic activity.

Medical uses

Retroprogesterones are used in HRT, contraceptive pills, and in the treatment of gynecological disorders such as dysmenorrhea, endometriosis, and menorrhagia. They are also used to prevent miscarriage and premature birth in pregnant women.

Side effects

Like all progestogens, retroprogesterones can have side effects. These may include breast tenderness, nausea, headache, and mood swings. However, due to their unique structure, retroprogesterones may have a lower incidence of side effects compared to other progestogens.

See also

• Progestin
• Progestogen
• Progesterone receptor
• Dydrogesterone