Dydrogesterone

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Dydrogesterone[edit | edit source]

Chemical structure of Dydrogesterone

Dydrogesterone is a synthetic progestogen, a type of medication that mimics the effects of the natural hormone progesterone. It is used in various gynecological conditions and hormone replacement therapy.

Pharmacology[edit | edit source]

Dydrogesterone is a retroprogesterone, which means it is a stereoisomer of progesterone. It has a similar molecular structure but differs in the spatial arrangement of its atoms. This unique configuration gives dydrogesterone its specific pharmacological properties.

Ball-and-stick model of Dydrogesterone

Mechanism of Action[edit | edit source]

Dydrogesterone binds to the progesterone receptors in the body, exerting progestogenic effects. It helps in regulating the menstrual cycle, maintaining pregnancy, and supporting the luteal phase in assisted reproductive technology.

Metabolism[edit | edit source]

Dydrogesterone is metabolized primarily in the liver. Its main active metabolite is 20α-dihydrodydrogesterone (DHD), which also possesses progestogenic activity.

Chemical structure of 20α-Dihydrodydrogesterone

Clinical Uses[edit | edit source]

Dydrogesterone is used in various clinical settings, including:

Comparison with Progesterone[edit | edit source]

3D chemical structures comparison of Progesterone and Dydrogesterone

Dydrogesterone is often compared to natural progesterone. While both have progestogenic effects, dydrogesterone is more selective in its action, with fewer androgenic and glucocorticoid effects. This selectivity can lead to a better side effect profile in some patients.

Side Effects[edit | edit source]

Common side effects of dydrogesterone include:

  • Nausea
  • Headache
  • Breast tenderness
  • Menstrual irregularities

Related Pages[edit | edit source]


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