Algestone acetophenide
Algestone acetophenide is a progestin medication which is used in hormonal contraception and in the treatment of gynecological disorders. It is not available in the United States or United Kingdom but is used in Latin America. The medication is often used in combination with estradiol enantate, a form of estrogen, under the brand name Perlutan.
Pharmacology[edit | edit source]
Algestone acetophenide is a progestin, or a synthetic progestogen, and hence is an agonist of the progesterone receptor, the biological target of progestogens like progesterone. It has strong progestogenic activity and weak glucocorticoid activity but no other important hormonal activity.
Chemistry[edit | edit source]
Algestone acetophenide, also known as algestone 16α,17α-acetonide or as 16α,17α-isopropylidenedioxyprogesterone, is a synthetic pregnane steroid and a derivative of progesterone and 17α-hydroxyprogesterone. It is more specifically a derivative of algestone, which was modified with the addition of an acetonide (16α,17α-isopropylidenedioxy) group in order to improve its pharmacokinetics.
History[edit | edit source]
Algestone acetophenide was introduced for medical use by 1963.
Society and culture[edit | edit source]
Algestone acetophenide is marketed widely throughout Latin America, including in Argentina, Brazil, Chile, Mexico, and Venezuela, but is not available in any predominantly English-speaking countries, including the United States and United Kingdom.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
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Contributors: Prab R. Tumpati, MD
