Tibolone

Information about Tibolone

Tibolone is a synthetic estrogen used for treatment of symptoms of menopause and prevention of osteoporosis.

Liver safety of Tibolone

Tibolone has been associated with rare instances of acute, clinically apparent liver injury.

Mechanism of action of Tibolone

Tibolone (tye' boe lone) is a synthetic estrogen-like steroid hormone which acts as an agonist of multiple type I steroid receptors and thus has weak estrogenic and progestational activities as well as some androgenic properties. The parent compound has no activity, but undergoes tissue-specific metabolism via a sulfatase to an active form which provides estrogenic effects without the need for concurrent progesterone administration. Tibolone also appears to have reduced estrogenic activity in breast tissue. It has been shown to be effective against the symptoms of menopause and in prevention of postmenopausal osteoporosis; it is approved in several European countries, but not the United States.

Dosage and administration for Tibolone

Tibolone is available as 1.25 and 2.5 mg tablets under the brand name Livial.

Side effects of Tibolone

Side effects include vaginal bleeding, abdominal pain, weight gain, bloating, breast tenderness, genital pruritus and vaginitis.

• Dailymed label info on Tibolone
• FDA Tibolone

Tibolone Resources
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