Testosterone buciclate

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Testosterone buciclate is a synthetic androgen and anabolic steroid (AAS) which was never marketed. It is an ester of testosterone and acts as a prodrug of testosterone in the body. Testosterone buciclate is designed to provide a long-lasting release of testosterone when administered via intramuscular injection.

Chemical Structure and Properties

Testosterone buciclate is chemically known as testosterone 17β-(3-cyclopentylpropionate). It is a testosterone ester, which means it is a form of testosterone modified to improve its pharmacokinetic properties. The esterification of testosterone at the 17β-hydroxyl group increases its lipophilicity, allowing for a slower release from the injection site and prolonged duration of action.

Pharmacokinetics

The pharmacokinetics of testosterone buciclate involve its slow release from the injection site into the bloodstream, where it is hydrolyzed to release free testosterone. This process allows for sustained levels of testosterone over an extended period, reducing the frequency of injections needed compared to other testosterone esters like testosterone enanthate or testosterone cypionate.

Clinical Use

Testosterone buciclate was developed for use in testosterone replacement therapy (TRT) for the treatment of hypogonadism in males. Hypogonadism is a condition characterized by low levels of testosterone, which can lead to symptoms such as decreased libido, fatigue, and loss of muscle mass. By providing a long-acting form of testosterone, testosterone buciclate aims to maintain stable testosterone levels and alleviate these symptoms.

Development and Market Status

Despite its potential benefits, testosterone buciclate was never marketed. The reasons for this are not well-documented, but it may be due to the development of other long-acting testosterone formulations or regulatory challenges.

Side Effects

As with other testosterone esters, potential side effects of testosterone buciclate include acne, gynecomastia, increased red blood cell count, and suppression of spermatogenesis. Long-term use of testosterone can also lead to cardiovascular issues, liver toxicity, and changes in cholesterol levels.

See Also

• Testosterone
• Testosterone enanthate
• Testosterone cypionate
• Testosterone replacement therapy
• Hypogonadism

External Links

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