Flumedroxone acetate

Flumedroxone Acetate is a synthetic, steroidal progestin that was never marketed. It is a derivative of progesterone and was synthesized in the late 1960s.

Chemistry

Flumedroxone acetate, also known as 6α-fluoro-17α-hydroxyprogesterone acetate, is a synthetic pregnane steroid and a derivative of progesterone. It is specifically a derivative of 17α-hydroxyprogesterone with a fluorine atom at the C6α position and an acetate group at the C17α position.

Pharmacology

As a progestin, flumedroxone acetate has progestogenic activity. It binds to and activates the progesterone receptor, thereby exerting its effects. Progestogens like flumedroxone acetate are responsible for changes in the endometrium that prepare it for implantation of a fertilized egg and maintenance of pregnancy.

History

Flumedroxone acetate was synthesized in the late 1960s as part of a series of modifications to progesterone aimed at improving its pharmacological properties. Despite its synthesis and initial study, it was never marketed.

See also

• List of progestogens
• List of steroidal progestins

‎