Norgesterone

Norgesterone is a progestin medication which was developed by Organon International but was never marketed. It is a synthetic steroid and a derivative of progesterone. Norgesterone is related to other progestins such as norethisterone and levonorgestrel.

Chemistry

Norgesterone, also known as 17α-vinyl-19-nortestosterone, is a synthetic estrane steroid and a derivative of testosterone. It is more specifically a derivative of nortestosterone (19-nortestosterone) and is a member of the gonane (18-methylestrane) subgroup of the 19-nortestosterone family of progestins.

Pharmacology

As a progestin, norgesterone is a agonist of the progesterone receptor (PR), the biological target of progestogens like endogenous progesterone. It has strong progestogenic activity and weak androgenic activity, but no estrogenic, glucocorticoid, or mineralocorticoid activity.

History

Norgesterone was developed by Organon International in the 1960s but was never marketed. It is one of the few 19-nortestosterone derivatives that has not been introduced for medical use.

See also

• List of progestogens
• List of androgens/anabolic steroids

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