Trengestone

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Trengestone is a progestin medication which is used in menopausal hormone therapy and for the treatment of gynecological disorders. It is taken orally.

Pharmacology[edit | edit source]

Trengestone is a synthetic, steroidal progestin of the 19-nortestosterone group. It has potent progestogenic activity and marked anti-estrogenic effects, but has no androgenic or glucocorticoid activity. Trengestone is a progestogen and acts as an agonist of the progesterone receptor, the biological target of progestogens like progesterone.

Medical uses[edit | edit source]

Trengestone is used in menopausal hormone therapy and for the treatment of gynecological disorders. It is used in combination with an estrogen in menopausal hormone therapy. The medication is used to prevent endometrial hyperplasia and endometrial cancer in women with an intact uterus who are receiving estrogen therapy.

Side effects[edit | edit source]

Side effects of Trengestone include menstrual irregularities, amenorrhea, and breast tenderness. It can also cause nausea, headache, and fluid retention.

History[edit | edit source]

Trengestone was first described in the literature in 1966 and was introduced for medical use by 1968. It is marketed widely throughout Europe and Latin America, as well as in certain other countries such as Morocco and South Africa.

See also[edit | edit source]

Resources[edit source]

Latest articles - Trengestone

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AI tools[edit source]

Generative AI tools and links to learn more on Trengestone: ChatGPT - Bing Chat - Google Gemini. (caution advised).


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