Russell bodies

Russell Bodies are eosinophilic, large, homogeneous immunoglobulin-containing inclusions usually found in a plasma cell undergoing abnormal maturational process. They were first described by a British pathologist named William Russell in 1890.

Overview

Russell Bodies are typically found in conditions where there is an overproduction of immunoglobulins, such as multiple myeloma and other plasma cell dyscrasias. They can also be seen in other conditions such as chronic inflammation and certain autoimmune diseases.

Appearance

Under the microscope, Russell Bodies appear as large, round, pink inclusions within the cytoplasm of plasma cells. They are often so large that they push the nucleus to the periphery of the cell, giving the cell a characteristic "signet ring" appearance.

Clinical Significance

The presence of Russell Bodies is a sign of a plasma cell's inability to secrete its immunoglobulins, which can be a sign of underlying disease. However, the presence of Russell Bodies alone is not diagnostic of any particular condition, and further testing is usually required.

See Also

• Mott cell
• Plasma cell
• Immunoglobulin

References

Russell bodies Resources
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