Sézary disease

Sézary disease is a type of cutaneous T-cell lymphoma, a group of lymphomas that affect the skin. It is named after the French dermatologist Albert Sézary who first described the condition in 1938.

Symptoms

The most common symptoms of Sézary disease include redness of the skin (erythroderma), intense itching (pruritus), and enlarged lymph nodes (lymphadenopathy). Other symptoms may include changes in the nails, hair loss, and palmar and plantar keratoderma.

Causes

The exact cause of Sézary disease is unknown. However, it is believed to be caused by changes in the T cells, a type of white blood cell that plays a key role in the body's immune response.

Diagnosis

Diagnosis of Sézary disease is based on a combination of clinical findings, blood tests, and skin biopsy. The presence of Sézary cells, abnormal T cells with a characteristic appearance, in the blood is a key diagnostic feature.

Treatment

Treatment options for Sézary disease include skin-directed therapies, systemic therapies, and stem cell transplantation. The choice of treatment depends on the stage of the disease and the patient's overall health.

Prognosis

The prognosis for patients with Sézary disease varies widely. Factors that can affect prognosis include the stage of the disease, the patient's age and overall health, and the response to treatment.

See also

• Cutaneous T-cell lymphoma
• Lymphoma
• Skin cancer

References

Sézary disease Resources
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