SB-271046

SB-271046 is a drug that acts as a potent and selective 5-HT6 receptor antagonist. It has been researched for its potential use in the treatment of cognitive and memory disorders such as Alzheimer's disease, but as of 2016, it has not been approved for medical use.

Pharmacology

SB-271046 is a potent and selective antagonist of the 5-HT6 receptor, a serotonin receptor that is expressed primarily in the brain. It has a high affinity for the 5-HT6 receptor, with a Ki value of 1.9 nM, and it is more than 200 times selective for the 5-HT6 receptor over other serotonin receptors.

Clinical significance

The 5-HT6 receptor has been implicated in the regulation of cognition and memory, and antagonists of this receptor, such as SB-271046, have been researched for their potential use in the treatment of cognitive and memory disorders. In animal studies, SB-271046 has been shown to enhance cognitive performance and improve memory. However, as of 2016, SB-271046 has not been approved for medical use.

See also

• 5-HT6 receptor
• Serotonin receptor antagonist
• Cognitive disorders
• Memory disorders

SB-271046 Resources
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