SGPT

SGPT or Serum Glutamic Pyruvic Transaminase is an enzyme that is usually found in a patient's liver cells. When the liver is damaged, SGPT is released into the bloodstream. An SGPT test measures the amount of this enzyme in the blood.

Overview

The SGPT test is a type of liver function test, which is often used to determine the health of the liver by measuring levels of liver enzymes in the blood. This test is often performed as part of a comprehensive metabolic panel, which also includes tests for other enzymes and substances in the blood.

Function

SGPT plays a crucial role in amino acid metabolism, and is involved in the transfer of amino groups from alanine to alpha-ketoglutarate. The reaction is as follows:

Alanine + Alpha-Ketoglutarate ↔ Pyruvate + Glutamate

This reaction is reversible, but in the liver the reaction is usually in the direction of glutamate and pyruvate.

Clinical significance

High levels of SGPT in the blood can indicate liver damage, such as that caused by hepatitis or alcoholism. However, SGPT can also be elevated in conditions affecting other parts of the body, such as the heart or muscles.

See also

• Liver function tests
• Alanine transaminase
• Aspartate transaminase

References

SGPT Resources
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