Transaminase

Transaminase is a type of enzyme that facilitates the process of transamination. Transaminases are crucial for the synthesis of amino acids, which are the building blocks of proteins. They are found in various organisms, including humans, and play a significant role in metabolism.

Function

Transaminases catalyze the transfer of an amino group from an amino acid to an alpha-keto acid. This process is known as transamination, and it is essential for the synthesis of amino acids. The two most commonly measured transaminases in human medicine are ALT and AST.

Clinical significance

Elevated levels of transaminases can indicate liver damage, as these enzymes are typically contained within liver cells. When the liver is injured, the cells release transaminases into the bloodstream, leading to increased levels. This can be detected through a blood test, and is often used as a diagnostic tool for liver diseases such as hepatitis and cirrhosis.

See also

• Aminotransferase
• Pyridoxal phosphate
• Liver function tests

References

Transaminase Resources
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