SLC2A2

SLC2A2 (also known as GLUT2 or Glucose transporter type 2) is a protein that in humans is encoded by the SLC2A2 gene. It is a member of the solute carrier family and is predominantly expressed in the liver, pancreas, and kidney.

Function

SLC2A2 is a facilitative glucose transporter. It is responsible for the passive transport of glucose, and other hexose sugars, amino acids, and other small solutes across cell membranes. It is a major glucose transporter in the hepatocyte membrane.

Clinical significance

Mutations in the SLC2A2 gene are associated with Fanconi-Bickel syndrome, a rare autosomal recessive disease characterized by hepatorenal glycogen accumulation, proximal renal tubular dysfunction, and impaired utilization of glucose and galactose.

See also

• Solute carrier family
• Glucose transporter
• Fanconi-Bickel syndrome

External links

• SLC2A2 at the US National Library of Medicine Medical Subject Headings (MeSH)

SLC2A2 Resources
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