SLC2A2
SLC2A2 (also known as GLUT2 or Glucose transporter type 2) is a protein that in humans is encoded by the SLC2A2 gene. It is a member of the solute carrier family and is predominantly expressed in the liver, pancreas, and kidney.
Function[edit | edit source]
SLC2A2 is a facilitative glucose transporter. It is responsible for the passive transport of glucose, and other hexose sugars, amino acids, and other small solutes across cell membranes. It is a major glucose transporter in the hepatocyte membrane.
Clinical significance[edit | edit source]
Mutations in the SLC2A2 gene are associated with Fanconi-Bickel syndrome, a rare autosomal recessive disease characterized by hepatorenal glycogen accumulation, proximal renal tubular dysfunction, and impaired utilization of glucose and galactose.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
- SLC2A2 at the US National Library of Medicine Medical Subject Headings (MeSH)
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Contributors: Prab R. Tumpati, MD
