SRT-1720
SRT-1720 is a drug developed by Sirtris Pharmaceuticals, which is a subsidiary of GlaxoSmithKline. It is a synthetic compound designed to mimic the beneficial health effects of resveratrol, a naturally occurring molecule found in red wine, which is believed to activate sirtuins, a class of proteins that are thought to play a role in aging.
Mechanism of Action[edit | edit source]
SRT-1720 is designed to bind to and activate SIRT1, a specific sirtuin that is believed to regulate certain metabolic processes, including the release of insulin, the breakdown of glucose, and the function of mitochondria, the energy-producing structures within cells. By activating SIRT1, SRT-1720 is thought to improve metabolic function and potentially extend lifespan, although this has not been definitively proven in humans.
Research and Development[edit | edit source]
SRT-1720 was first synthesized in 2007 as part of a research program aimed at developing drugs that could mimic the effects of a calorie-restricted diet, which has been shown to extend lifespan in a variety of organisms. Early studies in mice suggested that SRT-1720 could improve insulin sensitivity, reduce cholesterol levels, and extend lifespan, although these findings have been controversial.
In 2010, a study published in the journal Nature reported that SRT-1720 could protect mice against diet-induced obesity and insulin resistance, suggesting potential applications in the treatment of type 2 diabetes and metabolic syndrome. However, subsequent studies have yielded mixed results, and the drug is not currently approved for use in humans.
Safety and Efficacy[edit | edit source]
The safety and efficacy of SRT-1720 are still under investigation. While early studies in mice suggested potential benefits, subsequent research has yielded mixed results. Some studies have reported potential side effects, including liver toxicity, while others have found no significant adverse effects. Further research is needed to fully understand the safety and efficacy of SRT-1720 in humans.
See Also[edit | edit source]
- Resveratrol
- Sirtuins
- Sirtris Pharmaceuticals
- GlaxoSmithKline
- SIRT1
- Type 2 diabetes
- Metabolic syndrome
 | This pharmacology-related article is a stub. You can help WikiMD by expanding it. |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
