STAT5B

STAT5B is a protein that in humans is encoded by the STAT5B gene. It is a member of the STAT protein family and plays a crucial role in various cellular processes such as cell growth, cell differentiation, and apoptosis.

Function

STAT5B is activated by growth hormone and prolactin and mediates the expression of a variety of genes in response to cell stimuli, thus playing a key role in many cellular processes such as cell growth and apoptosis. The encoded protein is found in the cytoplasm and is translocated into the nucleus upon activation by cytokines.

Clinical significance

Mutations in the STAT5B gene have been associated with primary immunodeficiency, a condition characterized by recurrent infections and an increased susceptibility to autoimmune disorders. In addition, STAT5B has been implicated in the development of various types of cancer, including leukemia and lymphoma.

See also

• Signal transducer and activator of transcription
• STAT protein

External links

• STAT5B at GeneCards