STEAP4

STEAP4 or Six Transmembrane Epithelial Antigen of Prostate 4 is a protein that in humans is encoded by the STEAP4 gene. It is a member of the STEAP protein family, which consists of six transmembrane proteins primarily expressed in the prostate.

Function

STEAP4 is an iron and copper reductase, and it plays a crucial role in metabolism and inflammation. It is involved in the reduction of ferric iron (Fe3+) to ferrous iron (Fe2+), and cupric ion (Cu2+) to cuprous ion (Cu1+). This reduction process is essential for the uptake of these metals by cells, which is necessary for various cellular functions.

Clinical Significance

Alterations in the expression of STEAP4 have been associated with obesity, insulin resistance, and type 2 diabetes. Overexpression of STEAP4 has been observed in adipose tissue of obese individuals, suggesting a potential role in the development of obesity and related metabolic disorders. Furthermore, STEAP4 has been implicated in the regulation of inflammatory responses, and its dysregulation may contribute to chronic inflammatory diseases.

Research

Research on STEAP4 is ongoing, with studies focusing on its role in metabolic syndrome, cancer, and autoimmune diseases. Understanding the function and regulation of STEAP4 could provide new insights into the pathogenesis of these diseases and potentially lead to the development of novel therapeutic strategies.

See Also

• STEAP1
• STEAP2
• STEAP3