Sandimmune

Sandimmune (also known as Cyclosporine or Ciclosporin) is a medication primarily used to prevent organ rejection in transplantation surgery. It is also used in the treatment of certain autoimmune diseases.

History

Sandimmune was first discovered in 1971 from the fungus Tolypocladium inflatum. It was initially used in 1980 for kidney transplants and has since been used in a variety of other organ transplants.

Mechanism of Action

Sandimmune works by suppressing the body's immune response, thereby reducing the risk of organ rejection. It does this by inhibiting the activity of T cells, which are a type of white blood cell that can attack foreign substances in the body.

Uses

Sandimmune is used in a variety of medical contexts. Its primary use is to prevent organ rejection in transplant surgery. It is also used to treat certain autoimmune diseases, such as rheumatoid arthritis and psoriasis.

Side Effects

Like all medications, Sandimmune can have side effects. These can include kidney damage, liver damage, and an increased risk of infections due to the suppression of the immune system. It can also cause high blood pressure and high cholesterol levels.

See Also

• Immunosuppressive drug
• Organ transplantation
• Autoimmune disease