Scott W. Lowe

Cancer Biologist Scott Lowe

Scott W. Lowe is an American cancer biologist known for his contributions to the understanding of the genetic mechanisms underlying cancer. He is a member of the National Academy of Sciences and a fellow of the American Academy of Arts and Sciences.

Education

Lowe received his undergraduate degree in Biochemistry from the University of Wisconsin-Madison. He then pursued his Ph.D. in Biology at the Massachusetts Institute of Technology (MIT), where he worked under the supervision of Tyler Jacks.

Career

After completing his Ph.D., Lowe joined the faculty at Cold Spring Harbor Laboratory (CSHL), where he made significant contributions to the field of cancer biology. His research at CSHL focused on the role of tumor suppressor genes and oncogenes in cancer development and progression.

In 2011, Lowe moved to the Memorial Sloan Kettering Cancer Center (MSKCC), where he currently serves as the Chair of the Cancer Biology and Genetics Program. At MSKCC, his research continues to explore the genetic and molecular mechanisms that drive cancer, with a particular focus on apoptosis, senescence, and tumor microenvironment.

Research

Lowe's research has significantly advanced the understanding of how genetic alterations contribute to cancer. His work on the p53 tumor suppressor gene has been particularly influential. Lowe demonstrated that p53 plays a critical role in inducing apoptosis in response to cellular stress, thereby preventing the development of cancer.

He has also investigated the mechanisms of chemotherapy resistance and the role of epigenetics in cancer. His research has led to the identification of potential therapeutic targets and strategies for overcoming drug resistance in cancer treatment.

Awards and Honors

Lowe has received numerous awards and honors for his contributions to cancer research, including:

• Election to the National Academy of Sciences
• Fellowship in the American Academy of Arts and Sciences
• The Paul Marks Prize for Cancer Research
• The AACR Award for Outstanding Achievement in Cancer Research

Personal Life

Lowe resides in New York City with his family. He is actively involved in mentoring the next generation of cancer researchers and is a frequent speaker at scientific conferences and symposia.

See Also

• Cancer research
• Tumor suppressor gene
• Oncogene
• Apoptosis
• Senescence
• Tumor microenvironment

External Links

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