Spastic paraplegia 8

Alternate names

SPG8

Definition

A pure or complex form of hereditary spastic paraplegia characterized by a childhood to adulthood onset of slowly progressive lower limb spasticity resulting in gait disturbances, hyperreflexia and extensor plantar responses, that may be associated with complicating signs, such as upper limb involvement, sensory neuropathy, ataxia (i.e. mild dysmetria, uncoordinated eye movement) and mild dysphagia. Additional symptoms, including urinary urgency and/or incontinence, muscle weakness, decreased vibration sense and mild muscular atrophy in lower extremities, may also be associated.

NIH genetic and rare disease info

NIH info on Spastic paraplegia 8

Spastic paraplegia 8 is a rare disease.

Resources

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Spastic paraplegia 8
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