Spiramide

From WikiMD's Wellnesspedia

Spiramide is a synthetic antibiotic that is used in the treatment of tuberculosis. It is a derivative of isoniazid, a first-line anti-tuberculosis medication. Spiramide is not commonly used due to its potential for hepatotoxicity, or liver damage.

Mechanism of action[edit | edit source]

Spiramide works by inhibiting the synthesis of mycolic acid, an essential component of the cell wall of Mycobacterium tuberculosis, the bacterium that causes tuberculosis. This inhibitory action disrupts the integrity of the bacterial cell wall, leading to cell death.

Side effects[edit | edit source]

The most serious side effect of spiramide is hepatotoxicity, which can lead to liver failure and death. Other side effects include nausea, vomiting, and rash. Due to these side effects, spiramide is typically only used when other first-line treatments are not effective or cannot be used.

History[edit | edit source]

Spiramide was first synthesized in the 1950s as a derivative of isoniazid. Despite its potential for hepatotoxicity, it was used in the treatment of tuberculosis due to its effectiveness against Mycobacterium tuberculosis.

See also[edit | edit source]


Spiramide Resources

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Contributors: Prab R. Tumpati, MD