TAS1R1

TAS1R1 is a protein that in humans is encoded by the TAS1R1 gene. It is one of the three members of the Taste receptor family of proteins. TAS1R1 combines with another protein, TAS1R2, to form a G protein-coupled receptor that functions as a sweet taste receptor. This receptor is present in taste buds on the tongue and other regions of the mouth and throat.

Function

The TAS1R1 protein is a part of the class C group of G protein-coupled receptors, which are characterized by a large extracellular domain that forms a Venus flytrap module. This module is where the taste molecule binds. The TAS1R1 protein combines with the TAS1R2 protein to form a receptor that responds to the sweet molecules in food. When these molecules bind to the receptor, it activates the G protein, which then triggers a series of reactions that send a signal to the brain that something sweet has been tasted.

Clinical significance

Mutations in the TAS1R1 gene can lead to a reduced ability to taste umami, a savory taste that is often associated with meats and broths. This condition is known as ageusia. In addition, variations in the TAS1R1 gene have been associated with differences in individual's preference for sweet foods and their consumption of carbohydrates and alcohol.

See also

• Taste receptor
• G protein-coupled receptor
• TAS1R2
• Ageusia

External links

• NCBI Gene
• UniProt