TAS2R14

TAS2R14 is a protein that in humans is encoded by the TAS2R14 gene. It is a member of the bitter taste receptor family, which is a group of G protein-coupled receptors. This particular receptor is expressed in the taste buds on the tongue and is responsible for the detection of bitter compounds.

Function

The TAS2R14 receptor is part of the taste receptor, type 2 (TAS2R) family. These receptors are responsible for the perception of bitterness and are scattered throughout the oral cavity. The TAS2R14 receptor is known to respond to a wide variety of bitter compounds, including quinine, denatonium, and propylthiouracil.

Gene

The TAS2R14 gene is located on chromosome 12 in humans. It is one of approximately 25 functional TAS2R genes found in the human genome. The gene is approximately 1,000 base pairs long and consists of a single exon.

Clinical significance

Variations in the TAS2R14 gene have been associated with differences in taste perception, particularly the perception of bitterness. Some studies have suggested that these variations may influence dietary habits and potentially contribute to conditions such as obesity and diabetes.

See also

• Taste receptor
• G protein-coupled receptor
• TAS2R38

References

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