TMPRSS2

TMPRSS2 (Transmembrane protease, serine 2) is a protein encoded by the TMPRSS2 gene in humans. It is a member of the serine protease family and has been implicated in various biological and pathological processes.

Function

TMPRSS2 is an enzyme that aids in protein processing in the cell membrane. It is involved in the activation of the influenza virus and the human coronavirus, including SARS-CoV-2, the virus responsible for COVID-19. TMPRSS2 cleaves and activates the spike proteins of these viruses, enabling them to enter host cells.

Clinical significance

TMPRSS2 has been identified as a potential drug target for treating prostate cancer and COVID-19. In prostate cancer, TMPRSS2 is often overexpressed due to a gene fusion event with the ERG gene. In COVID-19, TMPRSS2 inhibitors are being investigated for their potential to block viral entry into cells.

See also

• Serine protease
• Prostate cancer
• COVID-19

References

TMPRSS2 Resources
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