TNFRSF12A

TNFRSF12A (Tumor Necrosis Factor Receptor Superfamily Member 12A) is a gene that encodes a member of the tumor necrosis factor receptor superfamily. This receptor is also known as FN14 and is the smallest member of this family. It is involved in various cellular processes, including cell proliferation, apoptosis, and inflammation.

Function

The TNFRSF12A gene product is a receptor for the cytokine TWEAK (TNF-like weak inducer of apoptosis). The interaction between FN14 and TWEAK can activate several signaling pathways, including the NF-kB pathway, which plays a crucial role in immune response and cell survival.

Clinical Significance

Alterations in the expression of TNFRSF12A have been associated with various diseases, including cancer, atherosclerosis, and autoimmune disorders. Overexpression of FN14 has been observed in several types of tumors, suggesting a role in tumor progression and metastasis.

Research

Research on TNFRSF12A is ongoing to better understand its role in disease and its potential as a therapeutic target. Studies are exploring the use of FN14 inhibitors in the treatment of cancer and other diseases characterized by chronic inflammation.

See Also

• Tumor necrosis factor receptor superfamily
• Cytokine
• Apoptosis
• NF-kB

External Links

• TNFRSF12A Gene - NCBI
• TNFRSF12A Protein - UniProt