TNFRSF12A
| Symbol | TNFRSF12A |
|---|---|
| HGNC ID | 11906 |
| Alternative symbols | – |
| Entrez Gene | 51330 |
| OMIM | 604967 |
| RefSeq | NM_016639 |
| UniProt | Q9NP84 |
| Chromosome | 16p13.3 |
| Locus supplementary data | – |
TNFRSF12A (Tumor Necrosis Factor Receptor Superfamily Member 12A) is a gene that encodes a member of the tumor necrosis factor receptor superfamily. This receptor is also known as FN14 and is the smallest member of this family. It is involved in various cellular processes, including cell proliferation, apoptosis, and inflammation.
Function[edit]
The TNFRSF12A gene product is a receptor for the cytokine TWEAK (TNF-like weak inducer of apoptosis). The interaction between FN14 and TWEAK can activate several signaling pathways, including the NF-kB pathway, which plays a crucial role in immune response and cell survival.
Clinical Significance[edit]
Alterations in the expression of TNFRSF12A have been associated with various diseases, including cancer, atherosclerosis, and autoimmune disorders. Overexpression of FN14 has been observed in several types of tumors, suggesting a role in tumor progression and metastasis.
Research[edit]
Research on TNFRSF12A is ongoing to better understand its role in disease and its potential as a therapeutic target. Studies are exploring the use of FN14 inhibitors in the treatment of cancer and other diseases characterized by chronic inflammation.
See Also[edit]
References[edit]
