TNFRSF12A

TNFRSF12A, also known as Tumor Necrosis Factor Receptor Superfamily Member 12A, is a protein that in humans is encoded by the TNFRSF12A gene. It is a member of the tumor necrosis factor receptor superfamily, a group of proteins that play a crucial role in controlling cell survival and death.

Function

TNFRSF12A is a cell surface receptor that is predominantly expressed in endothelial cells. It binds to a ligand known as TWEAK, which is a member of the tumor necrosis factor (TNF) family of cytokines. The interaction between TNFRSF12A and TWEAK triggers a series of intracellular signaling events that can lead to cell death, proliferation, or differentiation.

Clinical Significance

Mutations in the TNFRSF12A gene have been associated with various diseases. For instance, overexpression of TNFRSF12A has been observed in several types of cancer, including breast cancer and colorectal cancer. It has also been implicated in autoimmune diseases such as rheumatoid arthritis and lupus.

Research

Research into TNFRSF12A is ongoing, with studies focusing on its role in disease progression and potential as a therapeutic target. For example, drugs that inhibit the interaction between TNFRSF12A and TWEAK are being investigated for their potential to treat cancer and autoimmune diseases.

File:TNFRSF12A protein structure.jpg

The 3D structure of the TNFRSF12A protein. Image from Wikimedia Commons.

See Also

• Tumor necrosis factor receptor
• TWEAK
• TNF superfamily