TRPM3
TRPM3 is a member of the transient receptor potential (TRP) group of ion channels located in the cell membrane. It is encoded by the TRPM3 gene in humans.
Function[edit | edit source]
TRPM3 is a non-selective cation channel that is activated by pregnenolone sulfate, a neurosteroid. It is permeable to calcium, which allows it to play a role in calcium cell signaling. TRPM3 is expressed in a variety of tissues, including the brain, kidney, and cardiovascular system.
Clinical significance[edit | edit source]
Mutations in the TRPM3 gene have been associated with a rare form of intellectual disability known as autosomal recessive intellectual disability-16 (MRT16). This condition is characterized by severe cognitive impairment, muscle weakness, and seizures.
TRPM3 has also been implicated in the pathogenesis of pain and inflammation. It is activated by heat and inflammatory mediators, suggesting a role in nociception.
Research[edit | edit source]
Research into TRPM3 is ongoing, with studies investigating its role in various physiological and pathological processes. These include its potential involvement in cancer, diabetes, and neurodegenerative diseases.
See also[edit | edit source]
- Transient receptor potential channel
- Ion channel
- Neurosteroid
- Pregnenolone sulfate
- Calcium signaling
- Intellectual disability
- Nociception
References[edit | edit source]
Translate: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Navigation: Wellness - Encyclopedia - Health topics - Disease Index - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro) available.
Advertise on WikiMD
WikiMD is not a substitute for professional medical advice. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD