Thiazide-like diuretic

Thiazide-like diuretics are a class of diuretics used in the treatment of hypertension and edema. They are chemically different from thiazide diuretics, but have similar effects on the body.

Mechanism of Action

Thiazide-like diuretics work by inhibiting the sodium-chloride symporter in the distal convoluted tubule of the nephron. This results in an increase in the excretion of sodium, chloride, and water from the body, thereby reducing blood volume and lowering blood pressure.

Examples

Examples of thiazide-like diuretics include Indapamide and Chlorthalidone. These drugs are often used as first-line treatment for hypertension.

Side Effects

Common side effects of thiazide-like diuretics include hypokalemia, hyponatremia, and hypercalcemia. Less common side effects can include hyperglycemia, hyperlipidemia, and gout.

Interactions

Thiazide-like diuretics can interact with a number of other medications, including NSAIDs, lithium, and digoxin. These interactions can lead to changes in the effectiveness of the diuretic or the other medication, or increase the risk of side effects.

See Also

• Thiazide diuretics
• Loop diuretics
• Potassium-sparing diuretics