Thiomersal

Thiomersal is an organomercury compound used as an antiseptic and antifungal agent. It is a mercury-containing compound (approximately 49.6% mercury by weight) used as a preservative in vaccines and other biological and drug products.

History

Thiomersal was developed and registered under the trade name Merthiolate in 1928 by Eli Lilly and Company. It has been used as a preservative in vaccines, immunoglobulin preparations, skin test antigens, antivenins, ophthalmic and nasal products, and tattoo inks.

Uses

Thiomersal is very effective at preventing bacterial and fungal contamination of vaccines. It is used in the manufacture of many vaccines, including vaccines for hepatitis B, diphtheria, tetanus, pertussis, Hib disease, and meningococcal disease. It is also used in some skin test antigens and antivenins.

Safety

The safety of thiomersal in vaccines has been the subject of debate. The World Health Organization, the American Academy of Pediatrics, and the U.S. Centers for Disease Control and Prevention have stated that there is no convincing evidence of harm caused by the low doses of thiomersal in vaccines.

See also

• Mercury (element)
• Vaccine
• Preservative

References

Thiomersal Resources
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