Tienilic acid

Tienilic Acid is a diuretic medication that was previously used for the treatment of hypertension. It belongs to the class of medications known as thiazide diuretics, which work by helping the kidneys to get rid of excess water and salt.

History

Tienilic Acid was first synthesized in the 1970s by the French pharmaceutical company Laboratoires Fournier. It was marketed under the brand name Ticlid in France and Ticlopidine in other countries. However, it was withdrawn from the market in the 1980s due to concerns about its potential to cause serious liver damage.

Pharmacology

Tienilic Acid works by inhibiting the sodium-potassium-chloride cotransporter in the distal convoluted tubule of the kidneys. This results in an increase in the excretion of sodium, chloride, and water from the body, thereby reducing blood pressure.

Side Effects

The most serious side effect of Tienilic Acid is hepatotoxicity, or liver damage. Other side effects can include nausea, vomiting, diarrhea, and dizziness. Due to these side effects, Tienilic Acid is no longer used in clinical practice.

See Also

• Thiazide diuretics
• Hypertension
• Diuretics
• Hepatotoxicity

References

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