Tioclomarol
An anticoagulant medication
Tioclomarol | |
---|---|
![]() | |
INN | |
Drug class | |
Routes of administration | |
Pregnancy category | |
Bioavailability | |
Metabolism | |
Elimination half-life | |
Excretion | |
Legal status | |
CAS Number | |
PubChem | |
DrugBank | |
ChemSpider | |
KEGG |
Tioclomarol is an anticoagulant medication that is used to prevent the formation of harmful blood clots in the blood vessels. It is a coumarin derivative, similar to other anticoagulants such as warfarin.
Mechanism of Action[edit | edit source]
Tioclomarol works by inhibiting the synthesis of vitamin K-dependent clotting factors in the liver. These clotting factors include factor II, factor VII, factor IX, and factor X. By reducing the levels of these factors, tioclomarol decreases the blood's ability to clot, thus preventing thrombosis.
Pharmacokinetics[edit | edit source]
Tioclomarol is administered orally and is absorbed through the gastrointestinal tract. It is metabolized in the liver and excreted primarily in the urine. The drug has a long half-life, which allows for once-daily dosing.
Clinical Use[edit | edit source]
Tioclomarol is used in the prevention and treatment of venous thromboembolism, including deep vein thrombosis and pulmonary embolism. It is also used in patients with atrial fibrillation to reduce the risk of stroke.
Side Effects[edit | edit source]
Common side effects of tioclomarol include bleeding, bruising, and gastrointestinal disturbances. Patients taking tioclomarol require regular monitoring of their International Normalized Ratio (INR) to ensure that their blood is not too thin.
Contraindications[edit | edit source]
Tioclomarol is contraindicated in patients with active bleeding, severe liver disease, or hypersensitivity to the drug. It should be used with caution in patients with a history of peptic ulcer disease or hypertension.
Interactions[edit | edit source]
Tioclomarol can interact with a variety of medications, including antibiotics, antifungals, and nonsteroidal anti-inflammatory drugs (NSAIDs). These interactions can increase the risk of bleeding or reduce the effectiveness of tioclomarol.
Related pages[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD's Wellness Encyclopedia |
Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD