Topoisomerase inhibitor
Topoisomerase inhibitors are chemotherapeutic agents that interfere with the action of topoisomerase enzymes (topoisomerase I and II), which are crucial in DNA replication. These inhibitors can be divided into two groups: topoisomerase I inhibitors and topoisomerase II inhibitors.
Topoisomerase I inhibitors[edit | edit source]
Topoisomerase I inhibitors include camptothecin analogs. They work by stabilizing the complex of topoisomerase I and DNA, preventing the re-ligation of the DNA strand and leading to DNA damage.
Camptothecin analogs[edit | edit source]
- Irinotecan: Used in the treatment of colorectal cancer.
- Topotecan: Used in the treatment of ovarian cancer, cervical cancer, and small cell lung cancer.
Topoisomerase II inhibitors[edit | edit source]
Topoisomerase II inhibitors can be further divided into two groups: those that work by stabilizing the topoisomerase II complex (e.g., etoposide, teniposide) and those that work by intercalating into DNA and inhibiting topoisomerase II (e.g., anthracyclines, mitoxantrone).
Etoposide and teniposide[edit | edit source]
- Etoposide: Used in the treatment of testicular cancer, small cell lung cancer, and lymphomas.
- Teniposide: Used in the treatment of leukemia.
Anthracyclines and mitoxantrone[edit | edit source]
- Doxorubicin: Used in the treatment of a wide range of cancers, including breast cancer, lung cancer, ovarian cancer, and lymphomas.
- Mitoxantrone: Used in the treatment of prostate cancer and multiple sclerosis.
See also[edit | edit source]
References[edit | edit source]
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