Toxicokinetics

Toxicokinetics is the study of how an individual organism processes a toxic substance or poison. It is a sub-discipline of pharmacokinetics and is interested in how the body absorbs, distributes, metabolizes, and excretes toxins or poisons.

Absorption

Absorption is the process by which a substance enters the body. This can occur through various routes, including inhalation, ingestion, dermal absorption, and injection. The rate and extent of absorption can be influenced by factors such as the physical and chemical properties of the substance, the route of exposure, and the individual's physiological state.

Distribution

Once absorbed, a toxic substance is distributed throughout the body. The distribution process is influenced by factors such as the substance's chemical properties, the blood flow to various organs, and the affinity of the substance for different tissues.

Metabolism

Metabolism refers to the body's process of breaking down and eliminating the toxic substance. This can occur through various pathways, including oxidation, reduction, hydrolysis, and conjugation. The rate and extent of metabolism can be influenced by factors such as the individual's age, sex, genetic makeup, and overall health status.

Excretion

Excretion is the process by which the body eliminates the toxic substance or its metabolites. This can occur through various routes, including the urine, feces, breath, sweat, and breast milk. The rate and extent of excretion can be influenced by factors such as the substance's chemical properties and the individual's physiological state.

See also

• Toxicology
• Pharmacokinetics
• Pharmacodynamics
• ADME

References

Toxicokinetics Resources
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