Trilostane

Trilostane is a steroidogenesis inhibitor used primarily in the treatment of Cushing's syndrome. It is also used in the treatment of canine Cushing's disease, and for the treatment of hormone-dependent cancers.

Mechanism of Action

Trilostane works by inhibiting the enzyme 3β-hydroxysteroid dehydrogenase, which is involved in the production of several steroids including cortisol. Inhibition of this enzyme decreases cortisol production.

Medical Uses

Trilostane is used in the treatment of Cushing's syndrome. It is also used in veterinary medicine for the treatment of Cushing's disease in dogs. In addition, it has been used in the treatment of hormone-dependent cancers.

Side Effects

Common side effects of trilostane include nausea, vomiting, lethargy, and anorexia. In rare cases, it can cause severe hypoadrenocorticism.

Veterinary Use

In veterinary medicine, trilostane is used to treat Cushing's disease in dogs. It is also used to treat hyperadrenocorticism in ferrets.

See Also

• Cushing's syndrome
• 3β-hydroxysteroid dehydrogenase
• Cortisol
• Hormone-dependent cancers

References

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