Tropoflavin
From WikiMD's Food, Medicine & Wellness Encyclopedia
Tropoflavin, also known as 7,8-dihydroxyflavone, is a naturally occurring flavone found in Godmania aesculifolia, Tridax procumbens, and primula tree leaves. It has been discovered to act as a potent and selective small-molecule agonist of the tropomyosin receptor kinase B (TrkB) (Kd ≈ 320 nM), the main signaling receptor of the neurotrophin brain-derived neurotrophic factor (BDNF). Tropoflavin is both orally bioavailable and capable of penetrating the blood–brain barrier.
A prodrug of tropoflavin, known as R13 (and formerly, R7), is currently under development for the treatment of Alzheimer's disease. This prodrug aims to offer greatly improved potency and pharmacokinetics compared to tropoflavin. Template:Flavones
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Contributors: Prab R. Tumpati, MD
