Valperinol

Valperinol

Chemical structure of Valperinol

Valperinol is a pharmaceutical drug used primarily in the treatment of epilepsy and bipolar disorder. It is classified as an anticonvulsant and mood stabilizer. Valperinol works by increasing the levels of gamma-aminobutyric acid (GABA) in the brain, which helps to calm the nervous system.

Mechanism of Action

Valperinol enhances the inhibitory effects of GABA by inhibiting the enzyme GABA transaminase, which breaks down GABA. This results in increased GABA levels in the central nervous system, leading to a reduction in neuronal excitability and stabilization of mood.

Clinical Uses

Valperinol is primarily used in the management of:

• Epilepsy: It is effective in controlling various types of seizures, including absence seizures, tonic-clonic seizures, and myoclonic seizures.
• Bipolar disorder: Valperinol is used as a mood stabilizer to prevent manic and depressive episodes.

Side Effects

Common side effects of Valperinol include:

• Nausea
• Drowsiness
• Dizziness
• Weight gain

Serious side effects may include liver damage, pancreatitis, and teratogenicity.

Contraindications

Valperinol is contraindicated in patients with:

• Liver disease
• Known hypersensitivity to the drug
• Pregnancy, due to the risk of birth defects

Related Pages

• Anticonvulsant
• Mood stabilizer
• Epilepsy
• Bipolar disorder