Vasoactive intestinal polypeptide
Vasoactive intestinal polypeptide - a recombinant 28 amino acid neuropeptide that is chemically identical or similar to the endogenous vasoactive intestinal peptide (vip), with anti inflammatory and anti arthritic activities. This agent exerts a wide spectrum of anti inflammatory activity by inhibiting macrophage functions, including phagocytosis, respiratory burst, and chemotaxis, and also by inhibiting t cell proliferation and decreasing lymphocyte migration. Vip has also been reported to inhibit the production of pro inflammatory cytokines such as tnf alpha, interferon gamma, il 6, il 12, to reduce the activity of inducible nitric oxide synthase and to enhance the production of the anti inflammatory cytokines il 10 and il 1ra. This agent exerts its anti arthritic activity by reducing the titers of autoreactive antibodies against type ii collagen (cii), a major factor in determining susceptibility to collagen induced arthritis (cia).
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