Zinc finger protein 180

From WikiMD's Wellness Encyclopedia

Zinc finger protein 180 (ZNF180), also known as Zinc finger protein 180 or ZFP180, is a protein that in humans is encoded by the ZNF180 gene. This protein is a member of the zinc finger family of proteins, which are characterized by the presence of zinc finger domains. These domains are small protein motifs that can bind to DNA, RNA, or other proteins.

Structure[edit | edit source]

ZNF180 is a protein that contains several C2H2-type zinc fingers. The C2H2-type zinc finger is the most common type of zinc finger and is characterized by two cysteine residues and two histidine residues that coordinate a zinc ion. The zinc finger domains of ZNF180 are responsible for its ability to bind to DNA and potentially regulate gene expression.

Function[edit | edit source]

The exact function of ZNF180 is not fully understood. However, it is believed to play a role in gene regulation due to its ability to bind to DNA. Some studies suggest that ZNF180 may be involved in the regulation of cell growth and cell differentiation. Further research is needed to fully understand the role of ZNF180 in these processes.

Clinical significance[edit | edit source]

Alterations in the ZNF180 gene have been associated with several types of cancer, including gastric cancer and colorectal cancer. In particular, ZNF180 has been found to be downregulated in gastric cancer, suggesting that it may act as a tumor suppressor gene. Further studies are needed to confirm these findings and to explore the potential role of ZNF180 in cancer development and progression.

See also[edit | edit source]

References[edit | edit source]


WikiMD
Navigation: Wellness - Encyclopedia - Health topics - Disease Index‏‎ - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes

Search WikiMD

Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD

WikiMD's Wellness Encyclopedia

Let Food Be Thy Medicine
Medicine Thy Food - Hippocrates

Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.

Contributors: Prab R. Tumpati, MD