Metaxalone

Metaxalone

Muscle relaxant medication

Metaxalone
Trade names	Skelaxin
Chemical nomenclature
IUPAC name	5-[(3,5-dimethylphenoxy)methyl]-2-oxazolidinone
Routes	Oral
Metabolism	Liver
Half-life	9 hours
Excretion	Renal
Identifiers
CAS Number	1665-48-1
PubChem	4108
DrugBank	DB00544
ChemSpider	3967
UNII	7T8I6DK3RD
KEGG	D00765
ChEMBL	1200680
Chemical data
Chemical formula	C12H15N1O3
SMILES	O=C1N(COCC2=CC(OC)=CC(C)=C2)CCO1

Metaxalone is a muscle relaxant medication used to treat muscle pain and muscle spasms. It is marketed under the brand name Skelaxin. Metaxalone is typically prescribed as part of a comprehensive treatment plan that includes physical therapy and rest.

Medical uses

Metaxalone is indicated for the relief of discomfort associated with acute, painful musculoskeletal conditions. It is often used in conjunction with other treatments such as physical therapy and rest to enhance its effectiveness.

Mechanism of action

The exact mechanism of action of metaxalone is not fully understood. However, it is believed to work by depressing the central nervous system (CNS), leading to a reduction in muscle spasms and pain. Unlike some other muscle relaxants, metaxalone does not directly relax tense skeletal muscles.

Pharmacokinetics

Metaxalone is administered orally and is absorbed through the gastrointestinal tract. It is metabolized in the liver and has an elimination half-life of approximately 9 hours. The drug is excreted primarily through the kidneys.

Side effects

Common side effects of metaxalone include:

• Drowsiness
• Dizziness
• Nausea
• Vomiting
• Headache

Serious side effects, although rare, may include:

• Allergic reactions
• Liver damage
• Anemia

Contraindications

Metaxalone should not be used in individuals with known hypersensitivity to the drug or any of its components. It is also contraindicated in patients with significant liver or kidney impairment.

Interactions

Metaxalone may interact with other CNS depressants, including:

• Alcohol
• Benzodiazepines
• Opioids

These interactions can enhance the sedative effects of metaxalone and increase the risk of respiratory depression.

Dosage

The typical dosage of metaxalone for adults and children over 12 years of age is 800 mg taken three to four times a day. The dosage may be adjusted based on the patient's response and tolerance to the medication.

See also

• Muscle relaxant
• Muscle pain
• Muscle spasm
• Physical therapy