1,4-Dimethoxybenzene

1,4-Dimethoxybenzene is an organic compound with the formula C6H4(OCH3)2. It is one of three isomers of dimethoxybenzene. It is a white solid with a strong floral odor, reminiscent of jasmine. It is used in some fragrances and in certain chemical reactions as a precursor.

Structure and synthesis

1,4-Dimethoxybenzene is prepared by the Friedel-Crafts alkylation of hydroquinone with dimethyl sulfate and a strong Lewis acid, such as boron trifluoride or aluminium chloride. The reaction produces 1,4-dimethoxybenzene and methanol, which is removed by distillation.

Properties

1,4-Dimethoxybenzene is a white solid that is slightly soluble in water, but more soluble in organic solvents such as ethanol and diethyl ether. It has a strong, pleasant odor, similar to that of jasmine. It has a melting point of 57 °C and a boiling point of 212 °C.

Uses

1,4-Dimethoxybenzene is used in the synthesis of certain dyes and pharmaceuticals. It is also used as a fragrance in some perfumes and soaps, due to its pleasant odor.

Safety

1,4-Dimethoxybenzene is not considered particularly hazardous, but it can cause irritation to the eyes, skin, and respiratory tract. It is not classified as a carcinogen.

See also

• Anisole
• Veratrole
• 1,2-Dimethoxybenzene
• 1,3-Dimethoxybenzene

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